Well. In my opinion, Transhumanist era has already begun. We are in the beginning of the Twilight of an era without sunset.
Initially, by 2025-2030, we might see this begin as implants that help deep depression (I'm really waiting and in need for this), make people with disabilities as good as everyone else (it will most likely first begin with people with accident/trauma induced disabilities before soon progressing into people with congenital disabilities), improve focus and concentration, record and download your thoughts and to make your overall function and aesthetics, better. This might be something like new artificial skins made of materials like Graphene. We are already witnessing the twilight of the use of Graphene chips, which I hope will first be used for Medical applications (where cost is less of an issue), before transiting to other applications.
The next phase should arrive soon, where we will see transition from Brain chips and high tech body replacements/upgrades, to a more deeper level. For example, from 10% of the Brain being artificial in the previous phase to 50% or more of the Body including the Brain being upgraded. This begins to blur the difference between Biological lifeforms and AI Lifeforms. This dawns a new era, after which the progress will simply explode.
The next phase will be reached without even us knowing it, where we will transition to 100% uploaded brains, from the previous phase's 50-75%, which will lead to the beginnings of the Type-2 Civilization era, also called the "Dyson Sphere".
The progress beyond this stage depends on the Fundamental Physics of all existence. In my opinion, at that point, extensions of the Theory of Relativity, that explain about the fundamental interactions and the nature of Space and Time, will become more and more relevant, which will lead to a unified Theory of Everything in Physics. What comes after this? Omega Point Singularities that could have their present analogues in the Black Hole Singularities? A dissolution into something called an "Ultimate Existence"?
As a strong Physicalist, I generally believe that the interactions of Space and Time will eventually be discovered and solved, which is probably the key to a Timeless Omega Point Singularity, indistinguishable from God. I wonder what Einstein would have extended his theory to. However, Erwin Schrödinger makes a quote that hints at the above.